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found that mice show a reduced discrimination between CS+ and CS during threat learning (nicotine in a chronic schedule), which was mirrored by lower CS discrimination in humans that were smokers 14

Cigarette smoke but not electronic cigarette aerosol activates a stress response in human coronary artery endothelial cells in culture

Tobacco Control 23(2):133139

However, I worry that safer than cigarettes is often interpreted as safe, and that is not supported by the evidence

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